Analysis of the mechanism of severe pneunomia by influenza virus infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460568
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Hiroshima University
• Principal Investigator: Fukushi Masaya 広島大学, 大学院医歯薬保健学研究院(医), 助教 (50313515)
• Co-Investigator(Kenkyū-buntansha): SAKAGUCHI TAKEMASA 広島大学, 大学院医歯薬保健学研究院, 教授 (70196070)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: インフルエンザウイルス感染 / 重症肺炎 / 肺サーファクタント / 治療

Outline of Final Research Achievements

Infection with new influenza viruses, for example avian H5N1 virus, is known to have a high mortality rate. The main cause of death among these patients is acute respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD). However, no effective treatment for ARDS/DAD has been established. We previously reported that i) mouse-adapted influenza virus infection induced ARDS/DAD in the mouse lungs, ii) administration of artificial surfactant had a beneficial effect on mice infected with influenza virus.
In this study, we tried to reveal the mechanism of beneficial effect of the artificial surfactant to influenza virus-infected mice. In addition, the effect of the new type of artificial surfactant was examined.

Free Research Field

ウイルス学