Elucidation of mechanisms of innate immune stimulation and evasion by RNA viruses

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460569
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Hiroshima University
• Principal Investigator: Irie Takashi 広島大学, 医歯薬保健学研究院(医), 准教授 (70419498)
• Co-Investigator(Kenkyū-buntansha): SAKAGUCHI TAKEMASA 広島大学, 大学院医歯薬保健学研究院, 教授 (70196070)
• Co-Investigator(Renkei-kenkyūsha): ODA KOSUKE 広島大学, 大学院医歯薬保健学研究院, 助教 (60571255)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: RNAウイルス / 自然免疫 / パラミクソウイルス

Outline of Final Research Achievements

Host innate immune system is one of the primal host defense mechanism against invading pathogens, which is activated by recognizing pathogen-associated molecular patterns (PAMPs). In this study, we tried to elucidate what, where, and how the innate immune system detected the PAMPs in real viral infection by using Sendai virus (SeV), a prototype of mononegaviruses.
We elucidated 1. mechanism of viral counteraction against the host type-I interferon-responding pathway through physical interactions between the SeV C and host STAT1 proteins both in the cytoplasm and the nucleus, 2. mechanism of regulation of viral RNA synthesis by SeV C, 3. mechanism of production of the inneteimmune-stimulating viral RNA species and of host selective recognition of these unusual viral RNA species.

Free Research Field

ウイルス学