2015 Fiscal Year Final Research Report
Exploration for novel anti-enterovirus compounds and identification of its host targets
| Project/Area Number |
25460579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ARITA MINETARO 国立感染症研究所, その他部局等, 研究員 (70356244)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | エンテロウイルス / 抗ウイルス薬 / 宿主因子 / 複製 / PI4KB / OSBP |
|---|
| Outline of Final Research Achievements |
Idendified anti-enterovirus compounds were classified into direct-acting compounds to viral proteins, and PI4KB/OSBP inhibitors. PI4KB/OSBP pathway is required for formation of a virus replication complex by accumulating unesterified cholesterol on virus-induced membrane structure, rather than directly involved in viral RNA synthesis. These results suggested that evaluation of the effectiveness of the PI4KB/OSBP inhibitors is essential in development of anti-enterovirus drug targeting host factor activity.
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| Free Research Field |
ウイルス学
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