Analyses of the roles of CARD9-dependent innate immunity against protozoa infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460594
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Saga University
• Principal Investigator: Yoshida Hiroki 佐賀大学, 医学部, 教授 (40260715)
• Co-Investigator(Kenkyū-buntansha): HARA Hiromitsu 鹿児島大学, 大学院医歯総合研究科, 教授 (20392079)
• Co-Investigator(Renkei-kenkyūsha): MIYAMOTO Tomofumi 九州大学, 薬学研究院, 准教授 (40182050)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 原虫 / 自然免疫 / CARD9 / 炎症性サイトカイン / Th1

Outline of Final Research Achievements

In this study, we examined the role of CARD9-dependent innate immunity against protozoa infection. When infected with Leishmania major, CARD9-deficient mice demonstrated impaired resistance to infection with reduced inflammatory cytokine production at an early phase and impairment of Th1 response induction at a late phase of infection. CARD9, thus, is important in the initial defense and subsequent induction of Th1 responses during protozoa infection. By taking advantage of an ITAM-receptor protein library, we identified a couple of protozoa-binding receptors. One of the candidate receptors is shown to recognize carbohydrate motif on the surface of L. major.

Free Research Field

感染免疫