2016 Fiscal Year Final Research Report
Molecular basis of a new role of ficolin on endogenous homeostasis
| Project/Area Number |
25460596
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Endo Yuichi 福島県立医科大学, 医学部, 博士研究員 (20117427)
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| Research Collaborator |
SUZUKI Toshiyuki
ISHIDA Yumi
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | フィコリン (ficolin) / 自然免疫 / 恒常性維持 / レクチン / レクチン経路 / フィコリン欠損マウス |
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| Outline of Final Research Achievements |
Ficolins are recognition molecules in innate immunity. This study demonstrated that unlike ficolin 2, ficolin 1 was involved in recognition of self-cells in fetal tissues and leukocytes in adult circulation. Ficolin B (mouse ficolin 1) bound to several sialic acid-containing proteins in mouse fetal tissue and adult peripheral leukocytes. Ficolin B also recognized the N-acetyl group of N-terminal amino acid in ubiquitous cytoskeleton proteins in these cells, which are exposed during cell damage. In fetus, ficolin B formed the complex simply with MASP-3, a key enzyme of the lectin pathway, and in adult, ficolin B-MASP complex contained MASP-1, -2, -3, and regulatory proteins sMAP and MAp44. These results suggest that ficolin 1 has a role on endogenous homeostasis through the lectin pathway in both developmental and adult stages.
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| Free Research Field |
医歯薬学
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