2015 Fiscal Year Final Research Report
A study of T cell-mediated chronic inflammation in Alzheimer model mice
| Project/Area Number |
25460598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Shinei 順天堂大学, 医学研究科, 助教 (40432950)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アルツハイマー病 / 免疫 / アミロイドベータ / Ｔ細胞 / 炎症 / ワクチン |
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| Outline of Final Research Achievements |
Active immunization with amyloid beta peptide (Abeta) induced autoimmune encephalitis in humans, suggesting that Abeta-reactive encephalitogenic T cells exist in the peripheral blood and are involved in chronic inflammation of AD brain. In order to prove this, we tried to establish Abeta-reactive encephalitogenic T cell clones. After immunization of interferon-gamma mice with Abeta and Freund’s complete adjuvant, lymphocytes were obtained from popliteal lymph nodes and the spleen, and repeatedly stimulated with Abeta in the presence of interleukin-12. We could observe significantly higher proliferative responses against Abeta. However, while we are enriching Abeta-reactive T cells in vitro, we had mycoplasma infection in the laboratory, and this project is suspended.
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| Free Research Field |
神経内科学、神経免疫学、アルツハイマー病
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