2015 Fiscal Year Final Research Report
Regulation of T cell function by the epigenetic factor Eed
| Project/Area Number |
25460599
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Toho University |
|---|
Principal Investigator |
NAITO Taku 東邦大学, 医学部, 講師 (10568728)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | エピジェネティクス / Eed / IEL / TGFβ / PRC2 |
|---|
| Outline of Final Research Achievements |
The role of epigenetic regulation, which establishes and maintains semi-stable gene expression pattern without changes in DNA sequence, in T cell differentiation and function was investigated. When Eed, a gene encoding epigenetic factor involved in histone H3 methylation, was deleted specifically in T cells, proteins associated with a subset of gut IEL (intraepithelial lymphocytes) were highly induced by TGFbeta stimulation in CD4+ T cells. Moreover, the lymphocyte number in gut-affiliated lymphnode increased significantly. These results indicated that epigenetic regulation in T cells is involved in the homeostasis of gut immune system.
|
| Free Research Field |
免疫学
|
