Development of a method to attenuate the adverse effect of anti-arrhythmic bepridil

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460658
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Jichi Medical University
• Principal Investigator: Fujimura Akio 自治医科大学, 医学部, 教授 (90156901)
• Co-Investigator(Renkei-kenkyūsha): ANDO Hitoshi 金沢大学, 医学系, 教授 (50382875) ; KOSHIMIZU Takaaki 自治医科大学, 医学部, 准教授 (20392491) ; KAKEI Masafumi 自治医科大学, 医学部, 客員教授 (90214270) ; SHIGA Tsuyoshi 東京女子医科大学, 医学部, 准教授 (00277211)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 臨床薬理学 / 循環器 / 薬物有害反応 / QT延長

Outline of Final Research Achievements

Bepridil, an anti-arrhythmic drug, has beneficial clinical effects, but causes an adverse effect of QT prolongation leading to sudden cardiac death. In this study, we investigated the effects of alpha-lipoic acid (LA) on bepridil-induced QT prolongation, because LA can protect against arsenic trioxide-induced QT prolongation in guinea pigs. We found that LA dose-dependently attenuates bepridil-induced QT prolongation in guinea pigs, and that LA inhibits the formation of reactive oxygen species in H9c2 myocardial cells. Because alpha-tocopherol, an antioxidant, also attenuated bepridil-induced QT prolongation, LA appears to protect against the adverse effect at least through its antioxidant property.

Free Research Field

臨床薬理学