2015 Fiscal Year Final Research Report
Development of next-generation anticoagulant therapy using nutri-pharmaogenomic approach
| Project/Area Number |
25460661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ファーマコゲノミクス / 血栓 / 抗凝固薬 / 脂質代謝 / ビタミンK |
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| Outline of Final Research Achievements |
Intestinal cholesterol transporter NPC1L1-genotype dependent influence of dietary vit K intake on warfarin anticoagulation was examined in 232 patients. Only in those with VKORC1 -1639A/G heterozygotes, NPC1L1 functional SNP rs2072813 influenced significantly on the relation between warfarin efficiency and the amount of vit K intake, suggesting possible role of NPC1L1 linking lipid metabolism and thrombogenic diseases.
In subjects receiving novel anticoagulant, Xa inhibitor, Xa activity and several biomarkers were measured in 50 patients. F1+2 showed the best association with Xa activity among examined variables, and Xa activity in addition to sex, age, body weight, and creatinine was independent determinant for F1+2 level.
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| Free Research Field |
ファーマコゲノミクス
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