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2015 Fiscal Year Final Research Report

A novel therapy using Pirfenidone for muscular dystrophy and esophageal mucosal stenosis after endoscopic therapies

Research Project

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Project/Area Number 25460664
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionSojo University

Principal Investigator

UCHIDA Yuji  崇城大学, 薬学部, 准教授 (70433026)

Co-Investigator(Kenkyū-buntansha) KIMURA En  独立行政法人国立精神・神経医療研究センター, トランスレーショナルメディカルセンター, 室長 (60433025)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsピルフェニドン
Outline of Final Research Achievements

We focused the inflammation concerning macrophage that is the common key cell between muscular dystrophy and esophageal mucosal stenosis caused after endoscopic therapies. We investigated the amount of cytokine secreted by THP-1 cells induced by CSE or poly(I:C) by ELISA. The result showed that the increase of IL-8 is most obvious. So, we used IL-8 as a parameter of the effect of pirfenidone. Pirfenidone reduced IL-8. The system is simple and useful for the screening of drugs for chronic inflammation.

Free Research Field

神経内科

URL: 

Published: 2017-05-10  

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