2015 Fiscal Year Final Research Report
Comprehensive analyses and development of immunometric assay for plasmalogen
| Project/Area Number |
25460669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
Hui Shu-Ping 北海道大学, 保健科学研究院, 教授 (90337030)
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| Co-Investigator(Kenkyū-buntansha) |
千葉 仁志 北海道大学, その他の研究科, 教授 (70197622)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | プラズマローゲン / plasmalogen / エタノールアミン型 / コリン型 |
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| Outline of Final Research Achievements |
Plasmalogens (Pls) are glycerophospholipids owning antioxidative effect, so it is conceivable that Pls may prevent arteriosclerosis and Alzheimer's disease. In our study, chemical synthesis method for choline Pls (PlsCho) has been improved; chemical synthesis method for ethanolamine Pls (PlsEtn) has been established.
Comprehensively qualitative and quantitative analyses of Pls in human serum have been carried out by LC-MS/MS using the synthetic Pls standards. The concentration ofPlsEtn18:0/20:4shows higher than that of PlsCho18:0/20:4 in human serum. Some mouses were immunized with BSA-plasmalogens obtained from chemical synthesis.
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| Free Research Field |
臨床化学
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