2016 Fiscal Year Final Research Report
Phosphoproteomic analysis of RET kinase signal in MTC model mice
| Project/Area Number |
25460682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Kawai Kumi 名古屋大学, 医学系研究科(保健), 准教授 (50362231)
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| Research Collaborator |
YAMADA Norika
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | RET / 甲状腺髄様癌 / モデルマウス / プロテオミクス解析 / 分子標的薬 |
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| Outline of Final Research Achievements |
We examined the effect of multi-kinase inhibitor Sunitinib on MEN2A-RET thyroid medullary carcinoma cells, and Sunitinib presented remarkable inhibition of cell growth, migration and phosphorylation of down stream signaling molecules. Oral administration of Sunitinib to MoMuLV/RET-MEN2A mice exhibited significant tumor regression suggesting the promising effect of Sunitinib on MEN2A patients. LC/MS analysis on thyroid carcinoma tissue of MoMuLV/RET-MEN2A mice presented various interesting phosphotyrosine-binding proteins, and further analysis is required to elucidate the significance of these proteins in thyroid carcinogenesis.
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| Free Research Field |
実験病理学
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