Development of new examination methods for thrombotic tendency with TM resistance and FXa AT resistance

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Nagoya University
• Principal Investigator: TAKAGI AKIRA 名古屋大学, 医学(系)研究科(研究院), 准教授 (30135371)
• Co-Investigator(Kenkyū-buntansha): KOJIMA Tetsuhito 名古屋大学, 大学院医学系研究科, 教授 (40161913)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 病態検査学 / 静脈血栓塞栓症 / 危険因子

Outline of Final Research Achievements

Venous thromboembolism has attracted attention in recent years as economy class syndrome. In a congenital mutation of the blood coagulation factor control it has been known to increase the risk even in heterozygotes. We found an abnormal prothrombin to resist the control of the coagulation control factor antithrombin by one amino acid mutations, proposed an anti-thrombin resistance as a new disease concept. Thrombin loses the clotting ability to bind to receptor-thrombomodulin of vascular endothelial cell surface, so to exert an anti-clotting ability. We have developed a more of method for measuring changes in coagulation control ability of thrombomodulin by prothrombin mutation. In addition, we are focusing on the blood coagulation factor Xa inhibited by antithrombin.
We found abnormal FXs showing the antithrombin resistance. We have developed a method for analysis of FXa antithrombin resistance.

Free Research Field

病態検査学