2015 Fiscal Year Final Research Report
Stool DNA testing for detection of colorectal tumors
| Project/Area Number |
25460687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SUEHIRO Yutaka 山口大学, 医学(系)研究科(研究院), 准教授 (40290978)
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Naoko 山口大学, 医学部附属病院・副臨床, 衛生検査技師長 (40420541)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 大腸癌 / 便DNA検査 / メチル化 |
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| Outline of Final Research Achievements |
As TWIST1 methylation is specific to colorectal tumors, detection of TWIST1 methylation from stool samples might be useful for colorectal tumor screening. However, because the content of human DNA in stool is very small, it is very difficult to detect TWIST1 methylation by conventional bisulfite-based methylation assays. Therefore, we developed a new methylation assay without bisulfite treatment.
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| Free Research Field |
腫瘍学
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