2015 Fiscal Year Final Research Report
Systematic re-revaluation and construction of data repository regarding pre-analytical variables of clinical laboratory tests.
| Project/Area Number |
25460688
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Kyushu University of Health and Welfare (2015)
Yamaguchi University (2013-2014) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ICHIHARA Kiyoshi 山口大学, 大学院医学系研究科, 名誉教授 (10144495)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 臨床検査医学 / 臨床検査変動要因解析 |
|---|
| Outline of Final Research Achievements |
There have been a host of reports on pre-analytical variables in clinical laboratory(lab) tests. However,the test results had not been standardized,and the protocols were not comprehensible with inclusion of limited number of experimental conditions and test items. In this study,we planned to build a standardized data repository of experimental results on pre-analytical variables of common lab tests.
As an initial attempt,we have conducted five experiments. Effects of storage temperature (-30,-20,-10, 0, 4, 10, 25, 37°C) were examined. Most unstable was -10°C for many tests. Diurnal rhythm was observed prominently in iron and P. Effects of 30-min interval postural changes(PC) were analyzed by every 5-min sampling. For lab tests sensitive to PS, 20 mins was required for stabilization after PC. Menstrual cycle related changes were observed in HDL-C, Na,and TC. Additional experiments are planned to build a data repository truly useful for the practice of evidence-based lab medicine.
|
| Free Research Field |
病態検査学
|
