HLA and classification of diabetes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Ehime University
• Principal Investigator: Onuma Hiroshi 愛媛大学, 医学(系)研究科(研究院), 准教授 (00294794)
• Co-Investigator(Kenkyū-buntansha): Takata Yasunori 愛媛大学, 医学部附属病院, 講師 (20432792) ; Osawa Haruhiko 愛媛大学, 大学院医学系研究科, 教授 (90294800) ; Kawamura Ryoichi 愛媛大学, 医学部附属病院, 講師 (90533092)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HLA / 糖尿病 / GAD抗体

Outline of Final Research Achievements

The aim of this study is to perform new classification of diabetes by typing loci in HLA Class I and Class II(A, B, C, DR、DQ, DP) together with clinical information. We have collected 2700 samples of DNA and serum from diabetic patients and 2000 samples of those from control. HLA typing has been finished in 1200 DNA samples in diabetic patients and controls so far. GAD autoantibodies were determined in 2700 diabetic patients. GAD autoantibodies were detected in 10.2% in 1500 diabetic patients, which is higher than those in previous report in Japanese（Takeda H et al. Diabetes Care. 2002 25(6):995-1001）.

Free Research Field

糖尿病内科学