2015 Fiscal Year Final Research Report
The roles of STAT5B for gene regulation on human CD4+ T cells
| Project/Area Number |
25460697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Odaka Jun 自治医科大学, 医学部, 講師 (70382885)
Aoyagi Jun 自治医科大学, 医学部, 助教 (80438639)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 小児特発性ステロイド感受性ネフローゼ症候群 / T細胞 / 遺伝子工学 |
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| Outline of Final Research Achievements |
We revealed several genes that were regulated by STAT5B on human T cells. Some of the genes were corresponding to the phenotype of idiopathic steroid-sensitive nephrotic syndrome in children. When we analyzed the serum from the patients with idiopathic steroid-sensitive nephrotic syndrome, a substance was found which serum levels were associated with urinary protein/urinary creatinine levels. This is the first time to report the association of the substance and the status of idiopathic steroid-sensitive nephrotic syndrome. In next step, we are planning to find how the substance effects on the pathophysiology of idiopathic steroid-sensitive nephrotic syndrome.
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| Free Research Field |
小児腎臓病
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