Ischemia Modified Albumin is a possible marker of long-term hypoxia in respiratory disease.

2018 Fiscal Year Final Research Report

• Project/Area Number: 25460701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Showa University
• Principal Investigator: Kimura Satoshi 昭和大学, 医学部, 教授 (30255765)
• Research Collaborator: Gugliucci Alejandro C カリフォルニア州トウロ大学, 教授
• Project Period (FY): 2013-04-01 – 2019-03-31
• Keywords: 慢性呼吸不全 / 低酸素血症 / 虚血変性アルブミン / 比色法 / 血中マーカー

Outline of Final Research Achievements

Partial pressure of oxygen in arterial blood and oxygen saturation have been used as hypoxia markers. Since they represent only at the moment of measure, physicians cannot evaluate severity of hypoxia while patients are staying home.
Glyco-albumin represents degree of hyperglycemia in a recent week. With similar manner. Albumin is irreversibly altered to Ischemia-modified albumin (IMA) which can be assayed with colorimetric method. We found increased serum concentration of IMA in severe respiratory disease patients. With successful treatment, their IMA level decreased. Thus, we assume IMA could reflect ling-term hypoxia.

Free Research Field

臨床検査医学

Academic Significance and Societal Importance of the Research Achievements

気管支喘息など慢性的な呼吸不全患者において、予期せぬ突然の容態急変はよく遭遇する現象である。自宅や外出中に起きた発作の重症度を反映する「長期低酸素血症のマーカー」はいまだ確立されておらず、外来患者に対し迅速かつ安価に測定できるマーカーが求められてきた。我々の検査法は、「比色法」という非常に簡単な原理で実施できるため、将来は自動分析機に搭載し緊急検査にも応用できる。今後は実際に多くの症例の検討を行い、慢性呼吸不全患者のQOL向上に貢献したい