2016 Fiscal Year Final Research Report
The establishment of the noninvasive assessment method of diabetic angiopathy by the gingival microcirculation
| Project/Area Number |
25460704
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kanagawa Dental College |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 生活習慣病 / 糖尿病性血管障害 / 歯肉微小循環 / 非侵襲的評価方法 / 反応性充血 |
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| Outline of Final Research Achievements |
In common lifestyle-related diseases, peripheral vascular disorder occurs in the early stage. We measured a gingival vascular function of the diabetes animal model to examine an association between this vascular disorder and intraoral circulation. The gingival vascular function was reduced by diabetes, and this reduction deteriorated by periodontal disease. The alveolar bone resorption due to periodontal disease was enhanced by diabetes. Alternatively, in glomerule, reduction of the vascular plexus and luminal degeneration occurred by diabetes, and the rupture of the vascular wall was observed more by periodontal diseas. In addition, we demonstrated participation of the oxidative stress in gingival vascular disorder due to diabetes and periodontal disease. Above these results suggest that they cause peripheral vascular disorder due to diabetes in the oral cavity. In the near future, we may easily screen the risk of life-style related diseases by gingival blood flow.
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| Free Research Field |
循環薬理学
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