Diacetylspermine in urine, a tumor marker: studies on its clinical usefulness, metabolism, and simple and rapid determination

2016 Fiscal Year Final Research Report

• Project/Area Number: 25460714
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HIRAMATSU Kyoko 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (80181189)
• Co-Investigator(Renkei-kenkyūsha): TAKAHASHI Keiichi 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 客員研究員 (60443115)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: ジアセチルスペルミン / 腫瘍マーカー / 尿検査 / 大腸癌 / 肺癌 / イムノクロマト / 癌の早期発見 / 癌のフォローアップ

Outline of Final Research Achievements

This study was conducted to establish N1,N12-diacetylspermine (DiAcSpm) as a useful tumor marker, and to develop a simple and rapid procedure for DiAcSpm determination. Our study revealed that DiAcSpm was increased in early cancer tissues, and that this increase is responsible for the increased excretion of DiAcSpm in the urine of patients with early colorectal cancer patients. Further study indicated that preoperative urinary DiAcSpm level was significantly related with the risk of early recurrence of completely resected colorectal cancer and non-small cell lung cancer patients. We also developed an
immunochromatographic device for simple and rapid determination of urinary DiAcSpm. The simplicity of the procedure is a definite merit in promoting wider use of urinary DiAcSpm testing, a non-invasive and sensitive measure for early cancers.

Free Research Field

clinical chemistry