2015 Fiscal Year Final Research Report
Investigation for the histamine-related mechanism of neuropathic pain and development of its therapy
| Project/Area Number |
25460725
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
WATANABE Chizuko 東北薬科大学, 薬学部, 講師 (90296020)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ヒスタミン / 難治性疼痛 / 脊髄 / ポリアミン / NMDA受容体 |
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| Outline of Final Research Achievements |
On the state of neuropathic pain, histamine-evoked pain-sensation, which is mediated through the direct activation of polyamine-recognition site of NMDA receptor in spinal cord by histamine, is enhanced. On the other hand, the super-sensitivity of TRPV1 receptor on the planter skin of paw was revealed to induce the neuropathic pain. The results of this project suggest that the spinal polyamine-recognition site of NMDA receptor and TRPV1 receptor on the skin may be key targets to develop the new therapy for neuropathic pain.
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| Free Research Field |
疼痛制御
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