2015 Fiscal Year Final Research Report
Trigeminal contribution to the neurogenic inflammation in the dura mater
| Project/Area Number |
25460726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Mamoru 慶應義塾大学, 医学部, 講師 (60286466)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 片頭痛 / 硬膜 / 神経原性炎症 / 三叉神経 |
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| Outline of Final Research Achievements |
We explored the relationship between the trigeminal fibers distributing the facial region and the dura mater. This study revealed that some neurons in the trigeminal ganglion send nerve fibers to facial region and the dura mater. These results indicate that the trigeminal nociceptive stimulation in the facial region may cause the activation of the nerve fibers in the dura mater. According to these findings, we explored the effects of nociceptive stimulation to the facial trigeminal nerve, and observed the morphological change of the mast cells in the dura mater. We revealed that nociceptive stimulation to the facial trigeminal nerve cause the degradation of the mast cells in the dura mater. These data provide important clues regarding the pathophysiology of migraine.
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| Free Research Field |
片頭痛
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