A mechanism of spinal cord electrical stimulation-induced analgesia related to somatostatin

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460730
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Kansai University of Health Sciences
• Principal Investigator: Nakatsuka Terumasa 関西医療大学, 保健医療学部, 客員教授 (30380752)
• Co-Investigator(Kenkyū-buntansha): Taniguchi Wataru 和歌山県立医科大学, 医学部, 助教 (20453194)
• Co-Investigator(Renkei-kenkyūsha): Yamanaka Manabu 和歌山県立医科大学, 医学部, 学内助教 (30597084) ; Sonekatsu Mayumi 和歌山県立医科大学, 医学部, 学内助教 (40725579) ; Nishio Naoko 和歌山県立医科大学, 医学部, 特別研究員 (40648359)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 脊髄電気刺激 / パッチクランプ法 / in vivo パッチクランプ法 / 外向き電流 / SCS / slow IPSC / outward current / シグナル伝達

Outline of Final Research Achievements

Spinal cord electrical stimulation（SCS）is a kind of the effective treatments for a chronic pain．However, mechanisms of SCS-evoked analgesia have been poorly understood. In this study, whole-cell patch-clamp recordings were performed from dorsal horn neurons in rat spinal cord slices to investigate SCS-induced effects. SCS produced slow inhibitory postsynaptic currents (IPSCs). This action was suggested that activation of GIRK channels induced slow IPSCs via somatostatin receptors. Moreover, we analyzed the stimulation condition to get the largest slow IPSCs by SCS, although this study has a limitation because it was animal experiment.

Free Research Field

神経生理学