2015 Fiscal Year Final Research Report
The effects of the insulin resistance on the longitudinal trends by the mixed effects model of blood pressure and the metabolic factors in Japanese
| Project/Area Number |
25460770
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHONISHI Hirohumi 札幌医科大学, 医学部, 准教授 (20359996)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 健康診査 / mixed effects model / 血圧 / インスリン抵抗性 / 心血管疾患 / 疫学 |
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| Outline of Final Research Achievements |
In this study, we examined the effect of IR on the longitudinal trends of BP from young adulthood through eighth decade of life in a longitudinal cohort study.In Tanno-Sobetsu study, we had observed longitudinally 6,198 subjects who participated in every medical examination from 1998 to 2005. A total of medical examinations were made over the course of follow-up in 1,578 subjects. The effect of IR by Matsuda-Defuronzo index on longitudinal changes of blood pressure and metabolic CVD risk factor were estimated by modeling rate of change for 1,578 subjects based on 4,826 data points in mixed effects model. IR significantly predicted the natural histories of systolic blood pressure (SBP), diastolic blood pressure (DBP) and triglyceride (TG) adjusted for habitual drink, smoking, and body mass index in both male and female.
The natural histories of BP and TG were higher in subjects with the high IR group than in those of low IR group from young adulthood into the eighty decade of life.
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| Free Research Field |
健康科学
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