Generation of individualized risk prediction model for colorectal cancer and the impact on psychosocial and behavioral outcomes

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Hosono Satoyo 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (80402600)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 大腸がんリスク予測 / 健康教育 / 多因子疾患 / 遺伝カウンセリング

Outline of Final Research Achievements

(1) In a derivation case-control study, six single nucleotide polymorphisms were selected for synthesis of the genetic risk score. A dose-dependent association was observed between colorectal cancer risk and genetic risk score. The c statistic for a risk prediction model which included the genetic risk score and conventional risk factors was 0.7167, versus 0.7009 with the conventional risk factors only (P=0.0013). In a replication population, corresponding c statistics were 0.6356 and 0.6391 with no statistical significance. We could indicate the possibility of the risk prediction model for colorectal cancer in Japanese populations.
(2) We conducted a pilot study to evaluate the impact of a breast cancer risk prediction model on psychosocial, behavioral, educational, and communication outcomes. Adequate information for a risk prediction did not increase cancer worry among study participants and improved their health awareness.

Free Research Field

がん分子疫学