Longitudinal study of cardiovascular multi-biomarkers in long-time workers.

2017 Fiscal Year Final Research Report

• Project/Area Number: 25460795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Sugiyama Jogakuen University (2016-2017); Nagoya University (2013-2015)
• Principal Investigator: Hirai Makoto 椙山女学園大学, 看護学部, 教授 (90242875)
• Co-Investigator(Kenkyū-buntansha): 玉腰 浩司 名古屋大学, 医学系研究科(保健), 教授 (30262900)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 長時間労働 / バイオマーカー / small-dense LDL

Outline of Final Research Achievements

Long-time working increases cardiovascular diseases even in young workers. However, the mechanisms for this have not yet been elucidated. We analyzed biomarkers to clarify the pathobiochemical mechanisms involved in the development of cardiovascular diseases induced by long-time working in office and factory workers. We measured the followings twice (1-year interval): small dense (SD) low-density lipoprotein (LDL); total cholesterol; LDL cholesterol; high-density lipoprotein cholesterol. We also used questionnaires concerning smoking habit and body weight gain or loss time twice with 1-year interval. In smokers with overtime work, SD-LDL and the ratio of SD-LDL to LDL significantly increased however, LDL did not change significantly. In non-smokers with overtime work, only the ratio of SD-LDL to LDL increased significantly. Lowering SD-LDL might be of importance and beneficial in preventing cardiovascular events in office and factory workers with long-time working.

Free Research Field

循環器内科