Involvement of human PPARa in plasticizer DEHP-induced hepatic tumor

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460808
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Nagoya City University
• Principal Investigator: Ito Yuki 名古屋市立大学, 医学(系)研究科(研究院), 講師 (80452192)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Tamie 中部大学, 生命健康科学部, 教授 (10020794)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: フタル酸ジ-2-エチルヘキシル

Outline of Final Research Achievements

Di(2-ethylhexyl)phthalate (DEHP) is a major plasticizer for polyvinyl chloride products and used widely. On the other hand, carcinogenicity of DEHP has been drawn attentions for the last two decades. Functional species differences exist in the nuclear receptor to which metabolites of DEHP bind, therefore the hepatocarcinogenic response is thought to be not relevant to humans. Our experiments showed that DEHP induced hepatic tumors in humanized transgenic mice but the mode of action may differ from that in wild-typed mice.

Free Research Field

衛生学