2015 Fiscal Year Final Research Report
Basic research for cancer prevention by combinatorial treatment of food constituents based on the signal transduction pathways associated with carcinogenesis
| Project/Area Number |
25460809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hygiene and public health
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 予防医学 / 食品成分 / 癌予防 / 細胞増殖シグナル伝達系 |
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| Outline of Final Research Achievements |
The promising chemopreventive effects of food factors on malignant tumors have been reported extensively. However, desirable effects of treatment with a single agent mostly requires high doses, and there are many cases that are unachievable by an intake from food. It has been considered that various food-ingredients combined compositely show chemopreventive effects, but the evidence is still not enough. Paying attention to MEK-ERK and PI3K-Akt signal transduction pathways, considered to be one of the most important pathways for cancer development, it was shown that equol derived from soy, enhanced the inhibitory effect of brassinin, derived from brassica vegetables, on growth of human colon cancer cells via cell-cycle arrest and apoptosis. In addition, combination of emetine with cisplatin was shown to be useful for growth inhibition of human ovarian cancer cells.
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| Free Research Field |
医歯薬学
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