Dynamics of Pneumococcal carriage and emergence of high virulence clone after introduction of vaccine in Japan

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Osaka Prefectural Institute of Public Health
• Principal Investigator: Kawahara Ryuji 大阪府立公衆衛生研究所, その他部局等, 主任研究員 (10332454)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Hajime 佛教大学, 社会福祉学部, 教授 (30552806)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肺炎球菌 / ワクチン / 保菌 / 侵襲性感染症

Outline of Final Research Achievements

We investigated the impact of pneumococcal vaccine on carriage of Streptococcus pneumoniae and emergence of a high virulent clone in Japan. While the carriage rate didn't change than previous studies, the rate of vaccine-serotypes and non-vaccine-serotypes decreased and increase respectively. Furthermore, the result showed relatedness of serotype 15A, most frequently isolated in the study, between carriage and invative pneumococcal disease strains. Since most of the 15A strains were identical with Sweden15A-25, it is suggested that the 15A clone might be epidemic clone in the near future.

Free Research Field

病原細菌学