Self Evaluation of Patients with Psychosomatic disorders - Elucidation of the Neural Basis and Efficacy of Cognitive Behavior Therapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 25460884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku University
• Principal Investigator: Sato Yasuhiro 東北大学, 大学病院, 助教 (20375033)
• Co-Investigator(Kenkyū-buntansha): 田村 太作 東北大学, 大学病院, 助教 (60375029)
• Project Period (FY): 2013-04-01 – 2018-03-31
• Keywords: 心身医学 / 神経科学 / 摂食障害 / 機能性消化管障害

Outline of Final Research Achievements

Patients with psychosomatic disorders such as eating disorders and functional gastrointestinal disorders show poor self evaluation. Low self evaluation is relevant to onset and maintenace of the disorders. Social dysfunction by symptoms leads further impairment of self evaluation and these make a vicious circle. We conducted psychological evaluation of patients with eating disorders and acquired anatomical brain image, diffusion tensor image, and resting state functional magnetic resonance brain image. Patients of eating disorder showed poor Rosenberg's self-esteem scale score and showed thinner cortical surface in Precuneus and other regions than healthy controls. Resting state fMRI revealed that impaired functional connectivity between medial prefrontal cortex and temporal cortex which construct self-evaluation network.

Free Research Field

心身医学