A method for modifying inappropriate prescription in old patients

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: Taro Kojima 東京大学, 医学部附属病院, 助教 (40401111)
• Co-Investigator(Kenkyū-buntansha): AKISHITA Masahiro 東京大学, 医学部附属病院, 教授 (00261975) ; OTA Hidetaka 東京大学, 医学部附属病院, 助教 (20431869) ; ISHII Shinya 東京大学, 医学部附属病院, 助教 (80710996) ; KAMEYAMA Yumi 東京大学, 医学部附属病院, 助教 (60505882)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 多剤併用 / 減薬 / 薬物有害作用 / 高齢者

Outline of Final Research Achievements

In order to investigate the actual practice of decreasing drugs of old patients, 158 old inpatients (mean age (SD) 82.4 (6.7) y.o., male 46.5%) were enrolled. The number of drugs (mean (SD)) was 6.7 (4.3) on admission, and 6.1 (4.0) at discharge, and decrease in the number of drugs was observed in 34.1% of the patients. On multiple logistic regression analysis, male, low BMI, needs of care, and polypharmacy (drugs 6 or more) were associated with the patients whose drugs were decreased. Adverse drug reactions were observed in 11.1％ of the patients. however, the decrease of drugs was not associated with the adverse drug reactions. Therefore, it seems that the physicians are reviewing the drugs during the admission and have been controlling the prescription very carefully, especially male, dependent, and polypharmacy patients.

Free Research Field

高齢者薬物療法