2015 Fiscal Year Final Research Report
The investigation on the mechanisms of bone metabolic disorders caused by oxidative stress or Wnt/beta-catenin signaling pathway under type 2 diabetic condition
| Project/Area Number |
25460900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KIYOHARA NOBUAKI 島根大学, 医学部, 助教 (50733656)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 酸化ストレス / 骨質 / 骨脆弱性 / ２型糖尿病 / ホモシステイン |
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| Outline of Final Research Achievements |
We have reported that patients with type 2 diabetes mellitus have an increased bone fragility caused by poor bone quality because the elevated risk of fractures is observed despite their higher bone mineral density compared with non-diabetic subjects. However, any factors associated with poor bone quality remains unclear. Elevated levels of homocysteine and 8-OHdG, which are surrogate markers reflecting induction and tissue damages of oxidative stress, were significantly and positively associated with the presence of vertebral fractures independent of bone mineral density. These findings suggested that elevated oxidative stress was involved in aggravation of bone quality.
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| Free Research Field |
内分泌代謝学
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