2015 Fiscal Year Final Research Report
Relationship between white matter changes and cognitive/functional impairment :an association of amino acid transporter.
| Project/Area Number |
25460912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI KUMIKO 杏林大学, 医学部, 実験助手 (60398592)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 大脳皮質下病変 / 慢性脳低還流 |
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| Outline of Final Research Achievements |
In a mouse model of chronic cerebral hypoperfusion, inflammation markers were raised and astrocyte (GFAP) and microglia (iba1) increased significantly. As a behavioral change after chronic cerebral hypoperfusion, a decline of novel preference and a decline of curiosity were observed in young mouse and adult mouse over 60weeks old.
There was a difference of behavioral change after hypoperfusion between male and female mouse.
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| Free Research Field |
老年医学
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