Iron is associated with the development of hypertension

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460919
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Hyogo Medical University
• Principal Investigator: Naito Yoshiro 兵庫医科大学, 医学部, 講師 (10446049)
• Co-Investigator(Kenkyū-buntansha): MASUYAMA Tohru 兵庫医科大学, 医学部, 教授 (70273670)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高血圧 / 鉄 / 慢性腎臓病 / 肺高血圧症 / 内科学

Outline of Final Research Achievements

Iron is an essential element for life, while excessive iron contributes to increase the oxidative stress. We investigate the impacts of dietary iron restriction on the development of hypertension in experimental and clinical studies. Dietary iron restriction attenuated the development of hypertension in experimental hypertensive animals. The cellular iron import protein transferrin receptor 1 was increased in hypertensive damaged tissues (i.e. aorta, kidney). Although 3 months of dietary iron restriction did not significantly decrease blood pressure, iron restriction decreased cardio ankle vascular index in patients with essential hypertension.

Free Research Field

高血圧