Development of gastric cancer prevention and early cancer detection methods targeting changes in gastric microbiota

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460932
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: WATANABE TOSHIO 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
• Co-Investigator(Kenkyū-buntansha): FUJIWARA Yasuhiro 大阪市立大学, 大学院医学研究科, 准教授 (40285292) ; TOMINAGA Kazunari 大阪市立大学, 大学院医学研究科, 准教授 (80336768) ; TANIGAWA Tetsuya 大阪市立大学, 大学院医学研究科, 講師 (70423879)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胃細菌叢 / 胃癌 / ピロリ菌

Outline of Final Research Achievements

The Aim of this study is to clarify the role of the gastric microbiota using the 16S rRNA method. In this study, we especially focused on not only H.pylori infection but also other bacterial infections. We demonstrated that there are a lot of species other than H.pylori in the gastric mucosa. Interestingly, in some samples, H.pylori were not major component in the gastric mucosa which was obtained from H.pylori infected patients. Father studies are required to clarify the relationship between gastric carcinogenesis and involvement of the other bacterial species.

Free Research Field

消化器内科