Effect of decrease in gastric acid secretion on the intestinal microbiota and its associated diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460933
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Wakayama Medical University
• Principal Investigator: Kato Jun 和歌山県立医科大学, 医学部, 准教授 (90379743)
• Co-Investigator(Kenkyū-buntansha): ICHINOSE Masao 和歌山県立医科大学, 医学部, 教授 (50143425)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヘリコバクターピロリ / 萎縮性胃炎 / 腸内細菌 / 慢性炎症

Outline of Final Research Achievements

Helicobacter pylori infection induces atrophic gastritis with decrease in secretion of gastric acid, resulting in increase in pH in the gastrointestinal system. However, the effect of decrease in gastric acid secretion on the intestinal microbiota and diseases associated with microbiota has not fully been investigated. In this research, the changes of microbiota, and histological and genetic changes in the gut induced by decrease in gastric acid secretion were investigated by using a rat model. The results revealed that decrease in gastric acid secretion led to the specific change of microbiota, accompanied with site-specific histological inflammation in the gut and changes of gene expression in the intestinal mucosa. These results suggested the possible correlation between reduction of gastric acid secretion and microbiota-associated diseases.

Free Research Field

消化管疾患