2016 Fiscal Year Final Research Report
Control of intestinal mucosal defense system through IL-22 production: Crosstalk between IEL and IEC
| Project/Area Number |
25460948
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Sugimoto Ken 浜松医科大学, 医学部, 准教授 (20529507)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | IL-22 / IEL |
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| Outline of Final Research Achievements |
It is well known that IL-22 enhances the barrier mechanism of intestinal mucosa and is deeply involved in inflammatory response control, but it is not known whether it is involved in the mucosal defense mechanism of intractable ulcerative lesions in the small intestine. We confirmed that IEL isolated from mouse produces IL-22 and activates STAT 3 of small intestinal epithelial cells. In addition, in order to investigate the regulatory mechanism of IL-22 production in the small intestine and involvement in the mucosal defense mechanism against small intestinal epithelial cells, it was investigated whether IL-22 produced by IEL could improve mucosal damage of the small intestine induced by indomethacin by using the indomethacin-induced small intestine injury mouse model.
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| Free Research Field |
消化器内科学
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