Causal gene for chronic nonspecific multiple ulcers of the small intestine

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460953
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyushu University
• Principal Investigator: Umeno Junji 九州大学, 大学病院, 助教 (70621704)
• Co-Investigator(Kenkyū-buntansha): MORIYAMA Tomohiko 九州大学, 大学院病態機能内科学, 助教 (20452758) ; ESAKI Motohiro 九州大学, 大学院病態機能内科学, 講師 (50335957)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 小腸潰瘍症 / プロスタグランジン

Outline of Final Research Achievements

By using exome sequencing loss-of-function mutations in the SLCO2A1 gene encoding a prostaglandin transporter cause the hereditary enteropathy; chronic nonspecific multiple ulcers of the small intestine. We suggest a more
appropriate nomenclature of “chronic enteropathy associated with SLCO2A1 gene” (CEAS). CEAS and primary hypertrophic osteoarthropathy share a causative gene and that their clinical features are profoundly influenced by other modifiers.

Free Research Field

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