2015 Fiscal Year Final Research Report
Advances in refractory IBD treatment: a new therapeutic target, Annexin A2
| Project/Area Number |
25460957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Tanida Satoshi 名古屋市立大学, 医学(系)研究科(研究院), 講師 (30528782)
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| Co-Investigator(Kenkyū-buntansha) |
JOH Takashi 名古屋市立大学, 大学院医学研究科, 教授 (30231369)
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIYAMA Shigeki 愛媛大学, 大学院医学系研究科, 教授 (60202272)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | TNF-α / ADAM17 / Annexin A2 |
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| Outline of Final Research Achievements |
Inhibition of Annexin A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease inflammation.We try to propose the potential of Annexin A2 as a new molecular target for the treatment of IBD by using Annexin A2 knockout mouse. Annexin A2 knockout mouse cannnot be established becase chimera mouse's genital organ was immature. Annexin A2 is likely to be associated with mouse's genital organ formation.
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| Free Research Field |
消化器内科
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