Role of Hsp27 and SPARC in the carcinogenesis of colorectal cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460958
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Naito Yuji 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (00305575)
• Co-Investigator(Kenkyū-buntansha): UCHIYAMA Kazuhiko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50298428) ; TAKAGI Tomohisa 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70405257) ; ITO Tomoko (大矢 友子) 名古屋大学, 医学(系)研究科(研究院), 助教 (80329648)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 翻訳後修飾熱ショック蛋白質 / SPARC / バイオマーカー / 腸管粘膜免疫

Outline of Final Research Achievements

The present study has demonstrated that 1) methylglyoxal-modified Hsp27 protein (MG-Hsp27) and secreted protein acidic and rich in cysteine (SPARC) secreted from muscle play a crucial role in the carcinogenesis of colorectal cancer, 2) SPARC protein could reduce intestinal inflammation via the inhibition of inflammatory cytokines and activated T lymphocytes, and 3) serum levels of MG-HSP and SPARC did not changes in the clinical stages of colorectal cancers.

Free Research Field

消化器内科、下部消化管