2015 Fiscal Year Final Research Report
The role of Heme oxygenate-1 and carbon monoxide in the intestinal inflammation
| Project/Area Number |
25460959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Tomohisa Takagi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70405257)
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| Co-Investigator(Kenkyū-buntansha) |
Naito Yuji 京都府立医科大学, 医学研究科, 准教授 (00305575)
Katada Kazuhiro 京都府立医科大学, 医学研究科, 助教 (60593910)
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| Research Collaborator |
Mizushima Katsura
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | Heme oxygenase / 一酸化炭素 / マクロファージ / リンパ球 |
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| Outline of Final Research Achievements |
In this research, we investigated the role of heme oxygenase-1 (HO-1) and carbon monoxide (CO), which is a by-product of HO-1, in intestinal inflammation. In results, we confirmed that HO-1 highly expressing macrophages expressed M2 marker, and CO regulated Th1/Th17 differentiation of lymphocytes. Thus, HO-1 and CO might regulate intestinal immune system.
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| Free Research Field |
消化器病学
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