2015 Fiscal Year Final Research Report
Selective Imaging of Murine Colitis-Associated Dysplasia Using Activatable Fluorescent Probes
| Project/Area Number |
25460964
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 潰瘍性大腸炎 / 大腸癌 / 蛍光イメージング / 分子プローブ |
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| Outline of Final Research Achievements |
Patients with ulcerative colitis require repeated endoscopies for early etection of tumors, which, however, are frequently missed by standard colonoscopy. Ex vivo detection was performed by topical application of activatable probes to evaluate colitis-associated tumor lesions in mice and in humans. During ex vivo imaging, strong fluorescence signal was present in tumor. Circumscribed inflammatory lesion also had variable fluorescence but was lower in signal than tumor. The results clearly indicate clinical potential value of the probe for fluorescence-guided endoscopic detection of tumor associated with ulcerative colitis.
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| Free Research Field |
炎症性腸疾患
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