Development of HCC treatment by analyzing the induction of MDSC, TAM and Tregs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460970
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: Kondo Yasuteru 東北大学, 医学(系)研究科(研究院), 非常勤講師 (70455822)
• Co-Investigator(Kenkyū-buntansha): KOGURE Takayuki 東北大学, 大学病院, 助教 (70400330) ; KAKAZU Eiji 東北大学, 高度教養教育・学生支援機構, 助教 (20509377)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: HCC / MDSCs / PD-L1

Outline of Final Research Achievements

We quantified PD-L1+ MDSCs in various conditions of HCC patients by using multi-color flow cytometry analysis. PBMCs from HCC patients contained significantly higher percentages of PD-L1+MDSCs in comparison to those from healthy subjects (p < 0.001). After we cocultivated PBMCs and several liver cancer cell lines in a transwell coculture system, the percentages of PD-L1+MDSCs were significantly increased compared with control (p < 0.05).Peripheral blood from HCC patients had significantly higher percentages of PD-L1+MDSCs in comparison to those of healthy subjects, and the percentages of PD-L1+MDSCs were reduced by HCC treatment, suggesting that we might use PD-L1+MDSCs as a new biomarker of HCC.

Free Research Field

消化器病学