2015 Fiscal Year Final Research Report
Exosomal transfer of functional RNA in hepatocellular carcinoma cell proliferation
| Project/Area Number |
25460971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Yasuteru 東北大学, 医学系研究科, 非常勤講師 (70455822)
KAKAZU Eiji 東北大学, 高度教養教育・学生支援機構, 助教 (20509377)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 肝細胞癌 |
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| Outline of Final Research Achievements |
Ultraconserved RNAs are long non-coding RNAs transcribed from ultraconserved elements (UCEs), which are defined as genomic sequences with 100% conservation between human, mouse and rat with length of more than 200 bases and dysregulation of ultraconserved RNAs are reported in many types of cancers. We investigated the exosomal transfer of ultraconserved RNAs in hepatocellular carcinoma.
We identified several ultraconserved RNAs up-regulated in exosomes derived from hepatocellular carcinoma cell lines by using a custom PCR array plate and one of the ultraconserved RNAs were involved in the proliferation of hepatocellular carcinoma cells. We also identified an ultraconserved RNA differentially expressed in human hepatocellular carcinoma tissues.
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| Free Research Field |
肝臓病学
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