amino acids metabolism and immune abnormality in non alcoholic steatohepatitis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25460972
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KAKAZU Eiji 東北大学, 高度教養教育・学生支援機構, 助教 (20509377)
• Co-Investigator(Kenkyū-buntansha): KOGURE Takayuki 東北大学, 病院, 助教 (70400330) ; KONDO Yasuteru 東北大学, 医学系研究科, 非常勤講師 (70455822)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 非アルコール性脂肪性肝炎

Outline of Final Research Achievements

We elucidated the differences of metabolite profiles in portal blood between normal mice and fatty liver genetic model mice (ob/ob and kk-Ay) by CE-TOFMS. The top 5% metabolites of portal blood that were higher in ob/ob compared to wild-type were Trimethylamine N-oxide (TMAO), phenaceturic acid, isethionic acid, 3-Indoxylsulfuric acid and pipecolic acid. Furthermore, It is possible that TMAO or Trimethylamine (TMA) which is metabolized from TMAO, progress steatosis.

Free Research Field

肝臓学