2015 Fiscal Year Final Research Report
Basic study of immunotherapy for hepatocellular carcinoma by cytotoxic T cell receptor
| Project/Area Number |
25460984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 癌免疫療法 / Ｔ細胞レセプター / ペプチドワクチン / 肝細胞癌 / ＴＣＲ改変Ｔ細胞 |
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| Outline of Final Research Achievements |
In this study, we tried to develop an immunological method to induce a stronger and more efficient cancer immunity using cytotoxic T cell receptor as a cancer immunotherapy for hepatocellular carcinoma patients.
We characterized the cancer antigen-specific cytotoxic T cells induced by peptide vaccine in hepatocellular carcinoma patients. In addition, we could obtain some candidates of cytotoxic T cell receptors useful for immunotherapy of hepatocellular carcinoma and equipped the basic informations to perform clinical studies using the cytotoxic T cell receptors.
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| Free Research Field |
消化器内科
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