MicroRNA as a liver fibrosis marker in chronic hepatitis B

2015 Fiscal Year Final Research Report

• Project/Area Number: 25461006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: Enomoto Masaru 大阪市立大学, 大学院医学研究科, 准教授 (20423874)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI YOSHIKI 大阪市立大学, 大学院医学研究科, 准教授 (00397556) ; KAWADA NORIFUMI 大阪市立大学, 大学院医学研究科, 教授 (30271191) ; TAMORI AKIHIRO 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: B型慢性肝炎 / マイクロRNA

Outline of Final Research Achievements

In liver biopsy samples obtained from 35 patients with chronic hepatitis B, differences in some microRNA (miRNA) expressions were found between F1 and F2-4, between F1/F2 and F3/F4, and between F1-3 and F4, but not significantly. Regarding the IL28b and ITPA genotypes, about 60 miRNA expressions were significantly up- or down-regulated depending on the latter genotypes, some of which showed significant differences also in real-time PCR analysis. Some of circulating miRNA expressions, which were correlated with miRNA in liver, significantly changed during PEG IFN treatment.

Free Research Field

医歯薬学