Mechanism of formation of hepatic steatosis in Non-alcoholic fatty liver disease (NAFLD)

2016 Fiscal Year Final Research Report

• Project/Area Number: 25461007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: Hideki Fujii 大阪市立大学, 大学院医学研究科, 特任講師 (20382070)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: マクロファージ / 肝脂肪化 / MSR-A

Outline of Final Research Achievements

Mechanism of formation of hepatic steatosis in Non-alcoholic fatty liver disease (NAFLD). Macrophages actively uptake modified LDL (acetyl- and oxidized LDL) via macrophage scavenger receptors (MSR). In 1990, Kodama et al. isolated cDNAs encoding two versions of the bovine macrophage scavenger receptor, MSR-AI and MSR-AII. Functional MSR-As are trimers of 2 C-terminally different subunits generated by alternative splicing. A number of studies have reported the importance of MSR-A in the process of atherosclerosis.We have examined the mechanism of formation of hepatic fibrosis and carcinogenesis in Non-alcoholic steatohepatitis (NASH) using mouse model. In this research, we examined the role of macrophage in formation of hepatic steatosis using both in vivo and in vitro model.

Free Research Field

消化器内科学