2016 Fiscal Year Final Research Report
Mechanism of liver regeneration in regulation of sinusoidal remodeling through vascular nich
| Project/Area Number |
25461011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 肝再生 / 肝類洞リモデリング / 肝類洞再構築 / 肝類洞内皮細胞 / スフィンゴシン-1-リン酸 |
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| Outline of Final Research Achievements |
Liver has been well known to regenerate in response to injury as shown in two-thirds hepatectomy in rodents. It should be noted that regeneration following liver resection reflects compensative hyperplasia of cells, which is virtually proliferation and differentiation of hepatocytes. In this process, sinusoidal remodelling is important, because hepatocyte function cannot be maintained without blood flow that is formed by sinusoidal endothelial cells. In the present study, proliferation and migration of sinusoidal endothelial cells have been suggested to be crucial in liver regeneration.
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| Free Research Field |
肝臓病学
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