2015 Fiscal Year Final Research Report
Serum lipid biomarker for the prediction of non-B, non-C liver cancer development
| Project/Area Number |
25461013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Akira 東京医科大学, 医学部, 教授 (10468639)
MIYAZAKI Teruo 東京医科大学, 医学部, 講師 (60532687)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUZAKI Yasushi 東京医科大学, 医学部, 教授 (50209532)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 酸化ステロール / 非アルコール性脂肪性肝炎 / 非B非C肝細胞癌 / 胆汁酸 / 腸内細菌 |
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| Outline of Final Research Achievements |
Through the determination of profiles of serum bile acids (BA) in patients with NASH with or without HCC, a presence of specific serum BA pattern in NASH and NASH-HCC was demonstrated. This supports possible alteration of intestinal microbiota in these diseases as previously reported. However, as only modest change between NASH and NASH -HCC was observed, altered BA profile may not be a screening marker for high-risk group in HCC development among NASH patients.
Next, we employed an animal NASH model developing HCC, and determined BA profile as well as various oxysterol (OS) levels. Decrease of OS synthesized by enzymatic response and increase of OS induced by autoxidation have been seen in early phase of disease development. It is hypothesized that these qualitative differences in OS could influence the disease progression through the regulation of cholesterol accumulation in various hepatic cells..
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| Free Research Field |
消化器内科学
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